Hepatitis C

Hepatitis C

There are about 4 million Americans with the virus of hepatitis C. Near the 20 percent of this people will possibly develop the cirrhosis of the liver, followed by the cancer of the liver. Hepatitis C is the cause most common of the transplant of the liver in the United States.

Hepatitis C is an insidious viral disease because most people are unconscious of its initial infection. In place, the acute phase happens generally with minimum symptoms before giving to return in the chronic infection of hepatitis C. Much people has the disease per decades before it is diagnosed. They often diagnose to people with chronic hepatitis C as a result of the work of the blood realised for other medical conditions.

Chronic hepatitis C is dangerous because the virus makes the high levels of free radicals form in the liver. These free radicals put the serious tension oxidative in the liver, that exhausts protective antioxidants in the liver and kills possible to the cells of the liver. The disease is characterized per periods of the damage of the liver that fluctuates, with blazes of the acute hepatitis on the course of the infection. In a certain term, this constant attack against the causes of the liver marks with a scar the fine weave (fibrosis), that can lead to the cirrhosis if he is gone untreated.

The value of the antirust therapy in hepatitis C is supported by an extensive body of medical Literature, the antirust therapy still is not part of the standard care for people with chronic hepatitis C yet. Is essential that people with the chronic infection of hepatitis C learn on the foods that support a healthy liver and heighten the effectiveness of drugs of the prescription used to treat the disease.

Paper of the iron in the infection of hepatitis C

Hepatitis C inflicts the majority of their damage uniting on molecules of the iron, giving by result damage free-radical to the cells of the liver. Alternatively, the liver becomes inflamed, that can lead to the formation of the fine weave of the scar (fibrosis). If he is lazy wild, this damages constant will give rise to cancer of the cirrhosis or the liver.

Near 30 percent of people with hepatitis C they have very high levels of the iron. The reduction of the iron of the serum has been demonstrated to standardize the levels of the enzyme of the liver, that rise during periods of the active damage of the liver (Fong TL ET of a the 1998). The therapy of the exhaustion of the iron also has been demonstrated to improve the answer to conventional medicines used to treat the hepatitis (Fargion S ET a the 1997). The only effective way to diminish the iron of the serum is to have a loss of the iron, as it happens when donating blood. The patients of hepatitis C cannot donate the blood for the common use, but its blood can still be cleared, although it must be rejected.

Ferritin of the serum is a measurement of the amount of stored iron and it is used to direct therapy. A value of ferritin of the serum between 30 and 80 ng/decilitro is optimal. Many patients of hepatitis C have values of ferritin of the serum in the excess of 300 ng/decilitro.

In spite of substantial scientific evidence, nevertheless, few doctors put therapy of the iron-exhaustion in ejecucio'n before beginning therapy anti-virus. This partially considers the high percentage of failures of conventional drugs in the suppression of the virus (Boucher and ET of a the 1997; Martin-Vivaldi R ET to the 1997; Tsai NC ET to the 1997).

The phases of the infection of hepatitis C

The infection of the hepatitis progresses generally in a trustworthy and slow way. Near six weeks after the exhibition to the virus, people incorporate the acute phase of the infection. This stage of the disease is dismissed generally by the patient because it happens with very few, if any, the samples or the symptoms. To this point, the body has not even begun generally to make the antibodies to the virus, so a blood analysis can not reveal tracks to the infection.

If the analyses became of blood during the first times of the acute infection, it can be that they demonstrate aminotransferase high of alanine of serum (ALT), an enzyme of the liver that rises in response to the increasing tension oxidative in the liver (Hoofnagle JH 1997; Iwasaki M ET to the 2002), or one slight elevation of bilirubin, but enough not to cause sensible jaundice generally (yellowing of the skin). Approximately 75 percent of acute cases of hepatitis C do not have any observable jaundice (Esteban JI ET to the 1990). If the disease is detected in this stage, it is generally during the routine blood that tries for certain a another condition or before a medical procedure. The elevated levels of the ALT would alert to doctor to a possible infection with hepatitis C.

After the acute phase it raises, at least 70 percent of patients will develop chronic hepatitis C. This infection progresses very slowly and is marked by the episodes of the acute hepatitis characterized by the inflammation of the liver and the high ALT. Although the disease is transmissible in this time with blood, people can not recognize its infection by up to 20 years. , nevertheless, the nonspecific symptoms such as it tires urge possible generally patient to visit a doctor. The symptoms even are in this stage often very smooth, and the results of the laboratory consist of only the smooth elevations of enzymes ALT of the liver and of it aminotransferase of aspartate (AST).

If hepatitis C is suspected, a screen of the hepatitis must be requested. The disease can be diagnosed by the presence of the antibodies for hepatitis C or by the direct presence of the virus or viral products in the blood. If the screen is positive and the levels rise of the ALT, a biopsy of the liver is indicated. The results of the biopsy of the liver will be used to direct the treatment; the biopsy of the liver is not used to diagnose hepatitis C.

Once chronic hepatitis C is diagnosed, the treatment will begin. The goal of the conventional treatment is to prevent the progression with the disease being reduced the viral load in the blood. He is also crucial to reduce to the tension oxidative in the liver supporting healthy antirust levels and reducing the iron. After the initial period to 20-year, a disease of the liver more outpost begins to possibly become, possible leading to the lack of the cirrhosis and the liver (Jankovic S 1999; Amarapurkar D 2000).

Two subgroups of patients have a fast course much more: people with disease of the alcoholic liver and those that have concomitant infection with HIV. Hepatitis C in the presence of the disease of the alcoholic liver or HIV lies down for being severe and progresses more quickly than the infection of hepatitis only C. The patients who use the alcohol, that is toxic to the liver, can undergo a particularly fast progression of the disease. Due to this, it is essential that all the people with the use of the stop of hepatitis C of the alcohol.

Even in the absence of the use in course of the alcohol or the infection of HIV, hepatitis C he can not follow his typically slow course. Because a faster progression happens in some people is not known. The possibility of such fast progression does especially important to supervise the disease on a base in course and to obtain a biopsy of the liver in the initial presentation.

Hepatitis C is a leading cause of the cancer of the liver, that happens in 1 to 6 percent of patients with chronic hepatitis C (I gave Bisceglie A.M. 1997). The cancer of the liver only happens in the patients who have developed cirrhosis and have an inflammation in course. The cancer of the liver must be suspected if the following symptoms become which has chronic hepatitis C: the sudden worsening of the symptoms of the cirrhosis, such as it tires sharp, jaundice, and ascitis (accumulation of the liquid in the abdomen), and possibly hurts in the quadrant right superior of the abdomen.

The enzymes of the liver, including phosphatase alkaline, are generally very high when it happens the cancer of the liver, and exploration of the ultrasound or tomography computed of the abdomen reveals a mass within the liver. The biopsy of the liver of the mass confirms a diagnosis of the cancer of the liver. The patients with the cancer of the liver have a life limited without concerning the treatment.

Natural therapies

The conventional centers of the therapy of hepatitis C in the reduction of the viral load with the use of pegylated the interferon and ribavirin. Whereas this way of the therapy can be effective in the reduction of the viral account, it does not make anything deal with the damage in course of the liver caused by the virus about hepatitis C. During the infection hepatitis C, the liver is surrounded with the free radicals that consume the antirust interns and kill possible to the cells of the liver. (these dead cells send enzymes of the liver in the blood, that explains because the supervision of levels of the enzyme of the liver has value.)

There are some surrounding therapies of the controversy that are designed to lower levels of the enzyme of the liver. The levels of enzymes of the liver are not necessarily prophetic of viral activity or viral load. Nevertheless, the reduction of enzymes of the liver can provide a provable way to reduce damage of the liver.

Acid of Ursodeoxycholic. The acid of Ursodeoxycholic is a bile acid naturally that happens found in small amounts in the liver. A well-known synthetic form as help of ursodiol dissolves the biliary calculations in which they cannot have surgery of gallbladder or which they do not need surgery. Ursodiol has low toxicity of the liver. When it is taken as medication, it replaces some of more toxic bile salts of the liver. In the investigation related to hepatitis C, ursodiol jointly with the extract of liquorice has helped to standardize levels of transaminase in the patients of the hepatitis C that is resistant to the interferon (Tsubota To ET to a the 1999).

In a previous study, the investigators tried to 91 patients (47 men and 44 females) with disease of the chronic liver of hepatitis C. Assigned the patients randomly to receive ursodiol (magnesium 450) in bedtime for six months (44 patients) or no treatment (47 patients). One did not disclose any excellent side effects. The investigators found that ursodiol could perceivably reduce to serum ALT and levels of gamma-glutamyltransferase (GGT). These results lead investigators to be conceited that ursodiol could be an alternative for the patients who do not respond to the interferon or she is continued that she falls once interferon (Puoti C ET to the 1993).

Polyenylphosphatidylcholine. Polyenylphosphatidylcholine (PPC) is phospholipid naturally that happens found through body, particularly in membranes of the cell. One has demonstrated that administered oral PPC can be incorporated in the membrane of the cell of the liver to heighten their integrity. PPC attends the membrane of the cell in the determination of which she is safe to incorporate the cell as foods and of what is due to prevent of entrance, as toxins. Hepatocytes (cells of the liver) is typical examples of the cells that need the protection a vigilant membrane of the cell (Oneta cm ET of a the 1999). In patients with hepatitis C and the animal models of the hepatitis, PPC has been demonstrated to reduce levels of enzymes of the liver (CS 2004 of Lieber).

The evidence of the activity of the disease also was reduced perceivably in chronic active patients of the hepatitis in the therapy of phospholipid (Holoman J ET a the 1998). The regeneration of the cell of the liver was greater in those than they received PPC. Due to its nature multifaceted, administered oral PPC, a component of the lecitina, can have the potential to arrest and to invest the damage of the liver (Abakumova OI ET a the 1996).

PPC can also heighten the bioavailability of the several grass, drugs, and foods, including silibinin, the vitamin and, and interferon (Werner C ET a the 1990; Reizis AR ET to the 1992).

When PPC is administered jointly with the interferon, there is an increase in both his therapeutic values. In a study, they gave to the patients with hepatitis C the interferon (3 million IU, three times to the week by 24 weeks) and placebo or PPC (1,8 g daily). The investigators measured levels of the ALT and at least defined an answer as reduction of 50 percent. They found to 71 percent of participants of the study who took PPC underwent a drop of 50 percent in the ALT, compared to 51 percent in the placebo (Niederau C ET a the 1998).

In another study, a complex of silymarin (thistle of milk) and PPC were given to people with chronic active hepatitis. After seven days, 20 patients observed diminutions of AST, the ALT, and GGT. In addition, the levels of bilirubin and of phosphatase alkaline fell.

Selenium. The numerous studies have documented low levels of the selenium in patients of hepatitis C, and when it is used jointly with other antioxidants, it has been demonstrated to reduce to the tension oxidative in the liver. The level of the exhaustion of the selenium appears to correspond to the severity of the disease: the whichever advanced damage of the liver, major is the exhaustion degree. A study found that the patients cirrhotic of hepatitis C perceivably had lower levels of the selenium, glutathione, and vitamins To, patient Cs, and E that noncirrhotic and that all the patients of hepatitis C had lower levels of these antioxidants that the healthy controls of comparable age (Jain SK ET a the 2002). Another study examined to patients untreated of hepatitis C and found that the levels of the selenium and zinc were reduced perceivably and total the antirust state was lower in patients of the hepatitis C that in healthy controls (W ET a the 2005 of Ko).

Levels Of the Glutathione Of the Liver That they raise

Glutathione is the most important antioxidant used and made by the liver. Bush to the bacterial invaders, acts as ma's to detoxifier cellular, and the help prevents damage with free radicals. In patients with hepatitis C, particularly those that are positive of HIV, an exhaustion systemic of glutathione are observed, especially in the liver. This exhaustion can be an underlying factor the resistance to the therapy of the interferon and a biological base to replace with the following foods that raise the levels of glutathione (Moriya K ET a the 2001):

  • N-acetyl-n-acetyl-cysteine. the N-acetyl-n-acetyl-cysteine (NAC) is derived from the L-l-cysteine, an essential conditional amino acid. NAC is absorbed more efficiently and also it acts as antioxidant.
  • S-adenosyl-L-s-adenosyl-L-methionine. the S-adenosyl-L-s-adenosyl-L-methionine (the same) is an effective antidepressant that also help to the normal hepatic function regenerated increasing levels of glutathione and diminishing the activity of free radicals. She is one of the more important substances of hi'gado-proteccio'n of the body.
  • Acid of Lipoic. This acid is used by almost each fine weave in the body as combatant free-radical. Help also regenerated to other essential antioxidants and acts as chelator of the metal.
  • Insulator of the protein of the serum. This protein raises levels of glutathione and improves the operation of the immune system. The fact that hepatitis C often gets to be active in people after they reach the age of 40 indicates that the age-associate immune declination plays an important role in the progression of the disease.

Reduction of damage of free radicals

In addition to the supplements that raise glutathione, the antirust suplementación of the ample-phantom will help to protect the liver against damage against free radicals. The recent tests have examined therapy of hepatitis C with several antioxidants, including glycyrrhizin (of the extract of liquorice), silymarin, vitamin C, acid lipoic, glutathione, and vitamin E. a study, that listed to 50 patients of hepatitis C, assigned randomly to patients to one of these antirust groups by 20 weeks of the treatment. The antirust therapy almost gave rise to the favorable accounts for the levels of the enzyme of the liver, the levels of the RNA of the virus, or the accounts of the biopsy of the liver by half the patients. The normalization of enzymes of the liver happened in 44 percent of the patients who had elevated levels of the ALT before the treatment. The treatment was tolerated well between all the patients, having lead the authors to conclude that the treatment multi-antioxidant was beneficial in hepatitis C (Melhem To ET to the 2005).

In another study, a therapy of the combination of vitamin C and the vitamin and were proven for their capacity to protect the quotient of anti-inflammatory acid eicosapentaenoic (EPA) to favorable-inflammatory acid arachidonic. The investigators found that these two vitamins protected EPA in the liver of the people who were in the therapy of the combination interferon/ribavirin, that suggested these antioxidants could help to raise the effectiveness of the therapy of the combination (Murakami and ET of a the 2006).

Finally, in a study of the patients who were candidates to transplant of the liver due to severe complications of hepatitis C, an investigation equipment examined the effectiveness of a treatment of the combination of acid, silymarin, and the selenium lipoic. These foods were chosen because they protect the liver against damage oxidative, they raise the levels of other antioxidants, and interfere with the viral retort. In the end of the study, no of the three followed patients had undergone the transplant of the liver. In place, they had “recovered quickly and its laboratory values remarkable improved” (VM 1999 Of Berkson).

Foods De Liver-Protection

Silymarin and its main active ingredient, silibinin, are derived from thistle of milk, member of the family of the daisy. Both substances help to prevent toxic damage with the liver and to help the liver to regenerate after damage. Silymarin and silibinin really accelerate the index of the synthesis of the protein in the liver, leading to a faster regeneration of the cell (Sonnenbichler J ET to a the 1984, 1986a, 1986b; Valenzuela To ET to the 1994). Silymarin has produced a reduction of the levels of the enzyme of the liver in the patients of the hepatitis C (Mayer That ET a the 2005).

Some clinical ones have found that a combination of silymarin and silibinin, PPC, equal, selenium, and several supplements glutathione-that raise improvement not only results of the patients of hepatitis C treat that, but because produces few side effects that therapy conventional anti-virus (interferon and ribavirin), also the patient tariff of the exit falls.

The long term use of the extract by the root of liquorice (glycyrrhizin) has been demonstrated to be beneficial in the prevention of the inflammation, of the cirrhosis of the liver, and the hepatocellular carcinoma in the Japanese patients of the hepatitis C (Guyton KZ ET a the 2002; Kumada H 2002). Nevertheless, the seasoning of liquorice is not effective. A side effect possible associate to the ingestion of great amounts of liquorice is hypertension. Therefore, the arterial pressure must be supervised regularly if one is taking the root of liquorice.

Reduction Of Warehouses Of the Iron

The elevated levels of the iron of the serum are in people with hepatitis C and often cause to additional damage oxidative to the liver. Certain nutritional supplements have demonstrated the evidence to reduce levels of the iron of the serum. To help to maintain levels of the iron of the serum normal range loss from 30 to 80 ng/decilitro, the high green doses of polyphenols of the tea and high-allicin garlic can be beneficial.

Lactoferrin, subfraction of the protein of the serum, can be especially beneficial as treatment adjunctive for the overload of the iron of the serum in patients of the hepatitis. Lactoferrin is an antirust agent, powerful anti-virus, and cleaner of the free iron. In addition, lactoferrin is implied directly in upregulation of the activity of the cell of natural assassin, doing a natural modulator to him of the immune function (Yi M ET of a the 1997; Ikeda M ET to the 1998, 2000). As augmenter of immune pressure, lactoferrin has been demonstrated to work sinérgico with interferon to reduce the viral load (Ishii K ET a the 2003).

To take to 300 the magnesium of elementary calcium can reduce the absorption of the iron surrounds so much as 50 percent. When eating the rich iron foods, the patients of hepatitis C must consider taking from I supplement of calcium of the high-power in the same time (Hallberg L ET a the 1991).

Vitamin C

Linus Pauling the two-times winning of the Nobel prize shelp that vitamin C is very beneficial for the patients with hepatitis. it recommends a minimum of 10.000 milligrams = 10 grams per day. 20,000 - 50.000 milligrams per day are far better = 20 to 50 grams. Taking pure vitamin C. It takes tablets three to four times per day instead of once per day. Vitamin C is an antiviral agent. The only well-known side effect is the diarrhea, that would have to fall and to stop when you are accustomed to vitamin C. You can obtain books of Linus Pauling in your local library.

selenium
The deficiency of the selenium appears to heighten the virulence or the progression of some viral infections. The deficiency of the selenium gives rise to the activity diminished of would peroxidize of glutathione, increasing the probability of mutations in the viral genome induced in damage oxidative

The B12 Vitamin

Some patients with hepatitis declare to have more energy when they take extra B12 vitamin. It is important to notice that the B12 vitamin is not effective when is taken in the form of tablet. He must be injected.

Vitamin E

 

One says that to the vitamin and help to the liver to detoxificar the blood. The vitamin and is but effective when it is taken with selenium, an antirust mineral. Too much vitamin and adelgasa the blood, so the patients with coagulation problems must exert caution.

  The Root of Liquorice

The studies have shown that a liquorice component is effective for the treatment of hepatits viral, especially the active chronic hepatitis. This probably is due to its antiviral activity documented good.  

B12 hepatitis C

Powerful an antirust combination can protect the liver against damage in people with hepatitis C, diminishing possibly the necessity for a transplant of the liver. In a preliminary test, 23 three people with cirrhosis of the liver and varices of the esophagus (veins expanded in the esophagus that can break and cause the fatal drain) caused by hepatitis C received a combination of acid of the alpha-lipoic (300 magnesium twice to the day), silymarin (of thistle of milk; magnesium 300 three daily times), and selenium (selenomethionine; magnetocardiograma 200 twice to the day). After five to eight months of the therapy that included other “supplements of support,” for example vitamin C and vitamins of B, the three people had significant improvements in their hepatic function and total health. Greater clinical trials are necessary to confirm these preliminary results of promise.

The B12 vitamin (with or without acid folic) has been disclosed in tests as of years 50 to help to some people with hepatitis.24 the 25 injections of the B12 vitamin is probable to be more beneficial than the oral administration, although magnetocardiograma 1,000 (taken oral) every day can also be replaced.


 HEPATITIS C

A search of the Internet of “Google” for the “hepatitis” will secure almost four million to you answers; coincidently, that one is the approximated number of Americans with hepatitis C. It is not so any wonder that with himself so many questions on this disease. Immediately we cut to the persecution:

Administered immediately and in sufficient amount, vitamin C cures the whole alphabet of the hepatitis, To a E. that the intravenous infusion of vitamin C can be necessary to make the right of the work.

Roberto F. Cathcart, M.D., write in its Web site, http://www.orthomed.com:

“From the acute hepatitis To, B, C, etc., he cures himself easily with the massive doses of ascorbate, intravenous and with recordativa letter with the oral ascorbic acid, he is tragic that is not used correctly. Hepatitis C is a special problem because around a quarter of cases it only presents as acute (when it would be cured easily). Chronic hepatitis C is more of a problem; despite with the massive doses of oral ascorbic acid, a diet of the no-sugar, a vitamin and, of a selenium, silymarin (an antioxidant of thistle of milk), and of an acid lipoic of the alpha among others foods, never I have seen a case to go on acute hepatic necrosis or the cancer of the liver.”

I have known personally the people who took to oral vitamin C the tolerance of the intestine and the hepatitis of the blow. Also I have seen person only fail with the oral dosage, so nonvolume no occasions with Hep. To obtain the IV.