Infarct

Be cleaned the ostruidas can Arteries?

Can vitamin C, the Lisina and the Proline clean the ostruidas Arteries?

How it was discovered that the ostruidas Arteries can be cleaned?

How applied is the Treatment?

 

(Simplified Version)

 

THE UNIFIED THEORY OF THE CARDIOVASCULAR SUFFERING DE LINUS PAULING - REPAIRING IN NATURAL FORM

Much people have listened who Linus Pauling has some theory on vitamin C and the treatment on the cardiac suffering. That is known as “unified theory of human cardiovascular disease,” postulates that the deficiency of ascorbate is one of the leading causes of the cardiac suffering.

Using information collected of literally hundreds of studies published by scientists of world-wide class (MDs and PhDs), Pauling and their associated investigator, Matthias Rath, Md, they found the connection between the cardiovascular suffering and vitamin C.

In their “Unified Theory of Cardiovascular Human Disease,” the genetic differences are taken into account, in species that are susceptible to cardiovascular disease CVD.

The Unified Theory explains as the human organism precisely regulates the concentrations in cholesterol blood and provides evidence compelling that, with a suitable nutrition (and not with drugs) can not only be avoided the cardiovascular suffering but also be reverted it.

THE COMMON GROUND AND THE DIFFERENCES OF THE TWO THEORIES

As much the Lipid Theory as the Unified Theory agrees in that the plates atherosclerotic are deposited as answer to an injury of the walls of the blood glasses. The Drs. The Browns and Goldstein received Nobel Prize in Medicine in 1985 by this discovery.

The Paulings and Rath, nevertheless, have a concept different from cause and effect, when postulating that the genetic weakness of certain species (that they do not produce ascorbate endogenously) can be solved nutritionally, when stimulating healthful blood glasses.

Although the Paulings and Rath considered to the cholesterol clearly correlated with the cardiovascular suffering, did not consider to the cholesterol as enemy.

The Lipid Theory, on the other hand, postulates that cholesterol is the enemy. Consequently, those that support to the Lipid Theory recommend:

 Reducir the amount of cholesterol and lipids (“material of repair”) in the organism through diets and drugs

 Hacer the less sticky blood (by means of slimming of the blood as Coumadin, Plavix, aspirin, etc.), to assure an suitable flow the blood and to avoid attacks to the heart.

In order to understand better these theories, we approach one of my topical favorites: biochemistry.

THE SECRET OF THE BIOCHEMISTRY

Biochemistry is literally the “chemistry of life,” and, in my quality of pharmacist, this is one of my specialties. The Biochemistry helps to understand the structure and function us of the cellular components, as proteins, carbohydrates, lipids, nucleic acids and others biomolecules, just like reactions brought about by enzymes.

When I investigate something new, I like to understand what happens to molecular level. To make the marries for the Unified Theory, first must understand the paper of lipoprotein To, collagen and vitamin C.

Lipoprotein To or Lp (a)

The Lipoprotein To, also well-known as Lp (a), is another special cholesterol transporter (bus line) that only is in species that do not produce their own ascorbate (Vitamin C).

Just like LDL, the Lp (a) bus transports to two “bags” of cholesterol, that are covered with a protein cover called apo (a). This cover allows cholesterol to move through watery blood torrent. However, unlike LDL, the protein cover of Lp (a) is very sticky - it imagines to the “a” as “adhesive.”

In an animal that does not produce ascorbato, the amount of Lp (a) is inversely proportional to the amount of ascorbato in circulation. This means that high concentrations of vitamin C cause less production of sticky particles of Lp (a).

Under the effect of the stress and when is little vitamin C in circulation, the capacity of the Lp (a) it allows the organism to repair blood glasses damaged or injured and to avoid the death by hemorrhage.

This way, “the sticky” particles of Lp (a) circulate around the glasses and they stick to the points where is an injury of the wall of the blood glasses.

Due to the surface similar to Sailboat of the Lp (a), the particles in circulation of LDL also stick where the Lp (a) is repairing injured blood glasses, multiplying the process of the formation of the atherosclerosis.

Interesting facts About the Lp (a)

• The levels of Lp (a) estan influenced by genetics (inheritance) [7] • The diet does not influence in the levels of Lp (a)

• The drugs to reduce the cholesterol level have not demonstrated that they can reduce the levels of Lp (a)

• As much ascorbate (vitamin C) as the niacina (vitamin B-3) has demonstrated that they can reduce the levels of Lp (a)

  • Amino the natural acids L-lysine and L-proline, avoid that the outer shell (apo-a) of a transporter of Lipoprotein becomes sticky. These amino acids from to “Velcro” turns apo-a to “Teflon” quality. The L-lysine and the L-proline also help to eliminate plaque that enucuentra in the blood glasses (to preferentially to be combined with the receivers of Lp (a) and, thus, moving to the Lp cholesterol (a) of the arterial walls).
  • The Lp (a) is the factor of great risk but predicting restenosis of the blood glasses (the reduction of the blood glasses after widening in the open heart surgery)

 

Collagen

They collagen is much by the abundant protein but in the organism. Although one is a fiber, collagen acts as a “glue”, that maintains united to our cells. In fact they collagen is the preferred substance to repair to the organism, or to close wounds, to repair blood glasses, or to help to that the skin stays frees of wrinkles. [8]

The fiber of collagen is looked like a cord of three threads. The “cord” consists of a molecule thread of L-glycine, a thread of molecules of L-proline and a thread of molecules of L-lysine. These threads of chains of amino acids around plows twisted each to other in helical form and in fact they are looked like a cord.

When an injury appears and the collagen fiber is broken, the shabby terminals are swinged as if a cord was cut.

If ascorbate exists sufficient, amino acids in the broken ends hydroxylated. This means that “the terminal” molecules of L-glycine, lysine and proline becomes chemically to L-hydroxyglycine, L-hydroxylysine and L-hydroxyproline. This allows to sees spliced them back together (much like to sailor splicing to rope to together).

This simple chemical change also explains because vitamin C has the capacity, not only to repair the injury, but also to initiate the destruction of the existing plates, as side but ahead.

Of all the amino acids, the L-glycine is but simple chemically and, in general, always is in abundance in the organism. As much the L-proline as L-lysine, the other two amino acids in the collagen fiber, to however, not always is in abundance, reason why the organism needs supplementation to assure the synthesis collagen.

Vitamin C -- Ascorbic Ascorbate or Acid

By now, you May have surmised that vitamin C is the lynchpin of the Unified Theory. Vitamin C, or better the lack of sufficient ascorbate, has repercussions in practically any chronic disease -- osteoporoses, diabetes, arthritis, cancer, to spot degeneration, allergies, and chronic or re-occurring infections are only some examples.

Deafortunadamente, most people, including doctors, considers to vitamin C as the substance that it avoids to the scurvy. A small daily dose of 60 mgs is sufficient to avoid to the scurvy, and conventional wisdom you have been that additional vitamin C will just creates expensive to you urine.

The Paulings and Rath, nevertheless, postulated that the majority of the people suffers of chronic scurvy, semi-acute and that the cardiovascular suffering is only one of the symptoms of the underlying she disease.

Sometimes they bled its gingivae when one brushed its teeth?

Sometimes they bled the noses to him without apparent reason?

Sometimes it had a wound that queria not to heal to him?

If under, could have had a deficiency of ascorbate in its organism.

When a person suffers a chronic disease (which adds stress to the body and soon run out the reserves of insufficient ascorbate), they appear many symptoms tell-destroys of scurvy. True diagnosis generally is typically missed and the sequel of the scurvy plows instead are confused with symptoms of some chronic disease (i.e., delayed healing of hurt in diabetic, hemorrhages in diseases as Crohns and ulcerous colitis, etc)

Some excellent facts about vitamin C and of the cardiovascular one disease

  • During the 1950 ' s, a Canadian medical brilliant, the Dr. G.C. Willis, demonstró that vitamin C was related to the metabolism of cholesterol a deficiency of ascorbate brought about an increase of cholesterol (production).

When feeding animal with increasing amounts of cholesterol, their levels of vitamin C, and reducian, on the contrary, vitamin C supplementation reducia the levels of cholesterol.

 

The Dr. Willis also demostro that vitamin C podia to revert the atherosclerosis in little rabbits of Indians, a species that does not produce ascorbate endogenously. In 1971, the British doctor, Dr. Constance Spittle, demonstro that the patients with enfemedad cardiovascualr CVD presented a transitory increase in the blood cholesterol when the therapy of vitamin C was applied to them, whereas the patients which CVD do not padecian showed to the opposite, that is to say, low levels but of cholesterol in blood.

The explanation of Spittle: the therapy of vitamin C in fact was curing the walls of the glasses, eliminating the cholesterol of the existing plates at the same time. By the way, this study I publish myself in the British medical magazine of prestige, The Lancet.

  • Finally in 1985, when the Mevacor (the first drug statin) was the fashionable drug, the Dr. H.J. Harwood, Jr demostro that vitamin C was in fact “statin perfect of the nature.” The low levels of vitamin C detonate to the enzyme HMG-CoA Reductase to increase their activity and to catalyze (to stimulate) the synthesis (production) otherwise cholesterol to assure an adapted delivery “material of repair.”

 

Alternatively, the high levels of vitamin C detenian the enzymatic activity and brought about the fall of the levels of cholesterol.

The investigation of the Dr. Harwood ' demonstrates to a fundamental difference between drugs and nutrients: the drugs only can inhibit or accelerate a biochemical process whereas nutriceuticals allows the modular organism (i.e up regulates or to you down regulates to you) the enzymatic activity him based on real the physiological needs of the organism.

  • Another very important difference in the mechanism of action of statins exists if statins is compared with vitamin C. The, by to their mechanism of inhibition of HMG-CoA reductase, also stop production of enzyme CoQ-10.

 

Vitamin C on the other hand in fact increases to the production of this important enzyme. CoQ-10, which incidentally is transported in the blood torrent by lipoproteins also, is thought to sees first antioxidant that it is run out when LDL oxidizes thus furthering the plaque forming process.

The importance of this fact acquires knowledge because in 1989 the pharmaceutical giant, Merck, recibio one patents U.S. where statins” Mevacor and Zocor was authorized to them to add CoQ-10 to his “. Nevertheless, to the date, they have not seen any financial necessity to do it.

 

THE FINAL PIECES OF BREAK HEAD DE PAULING - L-LYSINE AND L-PROLINE

Pauling repitio many of the experiments already mentioned, and descubrio that vitamin C in fact helped to revert something training of plate in the heart disease (to remember, vitamin C chemically changes the amino end acid residues). Nevertheless, still existia the obstruction of the saguineos glasses in the experimental animal.

When remembering that the plates only form in the injured areas of the glasses - and that collagen damaged “parecia a shabby cord of three threads” -- I postulate that they deberian to exist sites of combination or connection (receiving) on the Lp (a) that serian specific for fragments of amino acids of collagen (glycine, lysine, and proline).

Being ubiquitous in the body, Pauling I discard to the L-glycine, reasoning that Lp (a) would not stick anywhere there is to glycine moiety (glycine particle).

The L-Lysine Is combined with Receivers Lp (a)

Pauling I immediately dedicate its attention to the L-lysine, postulating that the receivers of lysine on the Lp (a) for May account why Lp (a) stick exclusively to injured collagen fibers.

In order to understand what Pauling thought of lysine, it's useful to imagines the way in that the organism uses the antihistamine ones. An antihistamine one is combined with a histaminic receiver (you robs the car park you please if will) and this way avoids that the allergens from attaching and bring about an allergic reaction.

Similarly, Pauling I add L-lysine to vitamin C that it gave to the laboratory animal. Sure enough, the Lp (a) was made much less sticky and I eliminate great part of the plate.

 

The L-lysine behaves essentially as “a male” terminal of a pin for the receivers “female” in Lp (a). Thus it is as the Lp (a) is reconciled to broken threads - just like a pin in socket of wall.

 When an excess of L-lysine exists circulating in the blood torrent, the L-lysine “plugs in” to and seals Lp (a) ‘s “sockets”, thus creating to smooth, inert Lp (a) particle, that can be combined or no longer be adhered in the organism. It is just like it happens when a family father places a false pin in an empty plug - neither pin nor fingers can be connected.

Whereas the extra lisina “seals or covers to the plugs” on L (p) to, it remembers that vitamin C already change to the same “pin”. When turning to amino acids terminal in “hydroxyaminos”, it essentially replacement to the “pin standard” with a type of pin “European”. Now no longer all is for way AT the L (p) to “makes the connection.”

In tenth chemistry that reactants (here vitamin C and L (p different) a) has different affinities with the same substrate (the dangling amino acids of the broken collagen fiber)

 Reactant with the greater affinity would be combined preferentially with substrate and would already move reactants combined but with smaller affinity with the substrate (in this it marries, the “good guys” has major affinity and the “bad boys” become to a side).

For all these reasons, it is possible to be appreciated with clarity that the combination of L-lysine and vitamin C is in fact a powerful “destroyer of plaque”. This combination is, in fact, so powerful that the Paulings and Rath received a clear U.S. by a solution that contenia ascorbate and L-lysine to eliminate plates bodies donated before the transplant. [17]

You see, once a body migrates, the blood must travel profusely through new body or the weaves of the body can be necrosar (to die). When soaking the bodies to transplant in the solution of vitamin C-lysine before the transplant any plate in the great glasses was eliminated immediately but and increased the possibility of the success of the transplant. For Pretty impressive amino vitamin C and to lowly acid, don't you think?

The L-Proline is combined with Receivers Additional Lp (a)

Stimulated by the results with the L-lysine, Pauling and Rath they began to examine the L-proline. The L-proline is amino acid peculiar, with to five-member Ring structure, that contains the portion amine of the molecule (it's the only imino amino acid). The biochemical meaning of this is that the L-proline prefers to be in oil instead of water. So that the L-proline is lipophilic in contrast to the L-lysine hydrophilic.

Since the Lp (a) is a combination of water-loving protein (apo a) and the oily cholesterol, the Paulings and Rath postulated that lipophilic proline bloquearia any receiver that could exist in the oily portion of Lp (a). When they added L-proline to the solution of vitamin C-lysine, the effect was surprising. The obstruction desaparecio completely.

When counting on an excess of L-proline in the blood torrent (in addition to the supplemented L-lysine and vitamin C) all of the receiving sites on the L (p) “is sealed” and the molecule receives a “protection of Teflon”.

With sufficient abundance, vitamin C preferentially is combined to and hydroxylates (chemically alters) dangling lysine and proline ends (in area where the artery recibio an injury). After hydroxylation, the threads of lysine and proline in the walls of the glasses no longer “fit” in the receiving sites of the Lp (a) ‘, and some of the particles of the Lp (a) (or plaque patches) start to strip away of the walls of the glasses. Experiments of Willis and Spittle previously cited confirm this process.

  

In the case of the Unified Theory, it is considered to cholesterol, homocysteine, C-reactivates protein, and Lp (a) for what they really plows: the body's dire attempt to knows itself. These under-called “bad guys” is in fact indicating of undernourishment and proliferates to you when the organism is subject to stress. When dealing with the symptoms a nutritious deficiency with drugs becomes nothing dwells than an experiment, where we get to observes the toxic effects in an undernourished organism. Unfortunately, at present has been made tradition deal to the side effects with other drugs. And, in my profession, this is known as polypharmacy.

 

Medical Disclaimer: Educational Information provided in this article is for purposes only. Our Health Co makes not claims or representation regarding treatment, cures, or mitigation of any specific disease or condition. Please consult your own doctor, healthcare to practitioner, for and/or pharmacist any health problem (before deciding to self-treat or making any changes to your prescribed medications). If you plows ill, we recommend you see to qualified health professional.

 

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Graph 6. Scheme of the unified theory of the coronary disease of Pauling and Rath.